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Additional info for A Laplace mixture model for identification of differential expression in microarray experiments (200

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J. G. Thompson, an expert on the asbestos problem, predicted that asbestos lung cancer could overtake cigarette lung cancer very soon. "Morality" and Genital Cancer American Negro women have a higher rate of genital cancer (cervical carcinoma) than white American women. 8 Racial differences appear to be responsible for these differences, but stastistics can be deceiving. Investigations in a hospital for the poor in Louisville, Kentucky showed no differences between black and white. Instead it appeared that social standing could explain the cervical carcinoma rates, in this case low social status, coincident with early sexual relations, early age at marriage, and frequent births.

The reasons were simple: relatively few molecules are bound, and they can therefore be found only when highly radioactive compounds are used. Even with the use of such "hot" material, extreme care must be used in measuring techniques in order to detect the extremely low radioactivity present. Brookes and Lawley were the first ones to demonstrate conclusively that polycyclic hydrocarbons are bound to DNA. They found further that binding and carcinogenic activity appeared to be correlated, although Goshman and Heidelberger could not completely reproduce this correlation.

Polycyclic Hydrocarbons are Bound to Protein Polycyclic hydrocarbons give a strong blue-white to yellow-white fluorescence in ultraviolet light. Using this highly sensitive detection property, E. C. Miller discovered in 1951 that 3,4-benzpyrene is bound to mouse skin protein. These experiments were the out-growth of earlier experiments which succeeded in showing the binding of carcinogenic azo dyes to liver protein (see page 36). Apparently, then, carcinogens bind to proteins of the organs in which they induce tumors.

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A Laplace mixture model for identification of differential expression in microarray experiments (200 by Bhowmick D., Davison A.C.


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