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Phillips AN, Leen C, Wilson A, For the UK Collaborative HIV Cohort (CHIC) Study. Risk of extensive virological failure to the three original antiretroviral drug classes over long-term follow-up from the start of therapy in patients with HIV infection: an observational cohort study. Lancet. 2007;370:1923–8. The Strategies for Management of Antiretroviral Therapy (SMART) Study Group. Major clinical outcomes in antiretroviral therapy (ART)-naïve participants and in those not receiving ART at baseline in the SMART Study.

1993;118:390–2. 12. Klatt EC. Practical AIDS pathology. Chicago: ASCP press; 1992. 13. Vispo EA, Moreno AB, Maida IA, et al. Noncirrhotic portal hypertension in HIV-infected patients: unique clinical and pathological findings. AIDS. 2010;24:1171–6. 14. Dinh MH, Stosor V, Rao SM, Miller FH, Green RM. Cryptogenic liver disease in HIV-seropositive men. HIV Med. 2009;10:447–53. 15. Tolan DJ, Davies MH, Millson CE. The fibrosing cholestatic hepatitis after liver transplantation in a patient with hepatitis C and HIV infection.

Elvitegravir, a new InI that must be coadministered once daily with the pharmacokinetic booster cobicistat, is in the final phase of testing; [36] its resistance pattern overlaps significantly with raltegravir’s. S/GSK1349572 is a promising INI that can also be administered once daily and has activity against raltegravir-resistant virus; [37, 38] phase III studies are poised to start in late 2010. Still other agents with novel targets are in earlier stages of development. Individualizing antretroviral therapy is essential to maximizing the patient’s chance of success; in HIV disease management there is no ‘one size fits all’.

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Accuracy of Element Abundancies from Stellar Atmospheres by R. Wehrse

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