By Levels, Committee On Acute Exposure Guideline
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Extra resources for Acute exposure guideline levels for selected airborne chemicals : volume 14.
Neurologic signs were observed in seven of the eight subjects. 0 Source: Ketchum 1963. 9 Source: Ketchum et al. 1967. lower extremities that progressed to ankle clonus and progressive deterioration of normal gait. Subjects also reported uncomfortable paresthesias of the lower extremities and diffuse, nonspecific weakness of all extremities which manifested as an unsteady gait, truncal weakness when sitting, and slow response to rebound testing. Additionally dysarthria (slow, slurred, and difficult to produce speech) was also noted in the subjects.
3 mgmin/m3, which is similar but somewhat lower than the aforementioned point of departure of 20 mg-min/m3. In the absence of definitive concentrationresponse data, this comparison supports the point of departure for development of AEGL-2 values. Agent BZ (3-Quinuclidinyl Benzilate) 29 Data with which to assess the concentration-time relationship for BZ are not available. Experiments conducted by Ketchum and colleagues were of short durations; 6-8 min in animal studies and possibly no more than 5 min in tests with human volunteers.
Inhalation exposure would likely involve an aerosolized solid. Chemical and physical data on BZ are presented in Table 1-2. TABLE 1-1 AEGL Values for Agent BZ Classification AEGL-1 (nondisabling)a 10 min NR 30 min NR 1h NR 4h NR 8h NR End Point (Reference) Insufficient data. 011 mg/m3 NR NR Estimated threshold (20 mg-min/m3) for incapacitation in human volunteers (Ketchum et al. 1967). S. Department of the Army 1974) Abbreviations: NR, not recommended. a Absence of AEGL-1 values does not imply that exposure to concentrations less than the AEGL-2 values is without effect.
Acute exposure guideline levels for selected airborne chemicals : volume 14. by Levels, Committee On Acute Exposure Guideline