Adult and Embryonic Stem Cells - download pdf or read online

By Gülsen Ökten (auth.), Kursad Turksen (eds.)

ISBN-10: 1617796298

ISBN-13: 9781617796296

This quantity will conceal a chain of reports on stem cells together with grownup and embryonic stem cells. audio system have been invited to offer those talks in the course of the Stem cellphone Symposia in fall of 2010, in Samsun, Turkey. certain point of this quantity is that it brings a multidisciplinary point of stem cells extracted from a symposium.

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Later, this early, but transient, population is eventually replaced by MSCs derived from an as-yet-unidentified pathway. An important question raised by this study is what is the other source of MSCs? Until recently, MSCs have been described to derive from mesoderm, but the results presented by Takashima et al. 5 embryos could not generate MSCs. The authors speculate, on the basis of recent reports, that hematopoietic cells might constitute the progenitors of MSCs in adult bone marrow. However, one cannot rule out the possibility that in vitro conditions used in this study (2007) to measure the clonogenicity and the differentiation potential of PDGFRa + cells were not appropriate for revealing the MSC potential of mesoderm-derived cells.

2009) have documented the existence of similarities between MSCs and pericytes. A series of cell surface or intracytoplasmic structural proteins—some of which are site-, tissue-, and species-specific—are used to detect pericytes in vivo and in vitro (da Silva Meirelles et al. 2008; Crisan et al. 2008, 2009). 1 summarizes those pericyte markers, most of which were shared by MSCs. 16 A. Can Human pericytes sorted from diverse sources regenerate muscle, bone, and even skin in vivo and in organ cultures (Crisan et al.

2007; Battula et al. 2008, 2009; Martinez et al. 2007; Xu et al. 2009). 4 Differentiation Properties Another way to identify MSCs is to show differentiation capacities of the cells in vitro (Dominici et al. 2006). MSCs can transform into adipocytes, chondrocytes, osteocytes and neural cells with appropriate cytokine support (Deans and Moseley 2000; Pittenger et al. 1999; Abdallah and Kassem 2008; Arthur et al. 2008; Horwitz et al. 2002; Anselme et al. 2002; Mackay et al. 1998; Caplan 1991; Salem and Thiemermann 2010; Jackson et al.

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Adult and Embryonic Stem Cells by Gülsen Ökten (auth.), Kursad Turksen (eds.)

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