Get Cancer: Experiments and Concepts PDF

By R. Süss, V. Kinzel, J. D. Scribner (auth.)

ISBN-10: 038790042X

ISBN-13: 9780387900421

ISBN-10: 1461298415

ISBN-13: 9781461298410

This ebook quite must be learn on holiday, only for leisure. Granted, melanoma is, actually, a dangerous critical subject, and melanoma examine is essentially part of medication with Hippocrates in its again­ floor. but, melanoma study can also be typical technological know-how, and as such it yields the thrill and sorrows of any technological know-how. The melanoma challenge is usually a mind teaser, a problem for the curious. This introductory record on experimental melanoma learn is there­ fore directed to curious scholars of many disciplines: certainly to clinical scholars, but in addition to chemists and physicists who've an curiosity in organic phenomena; biology scholars would certainly en­ counter pr9blems extraordinary to their box in what's supposedly a medi­ cal one. now we have tried to jot down with out assumptions to a definite measure, for a chemist is largely in over his head in drugs, and a doctor has purely the slightest inspiration of the chemical difficulties im­ portant in melanoma study. We had no goal of giving a whole view of the sphere, and from the massive variety of diversified strains of improvement we have now selected just a couple of. Chemotherapy, as an ex­ abundant, has been taken care of fairly cursorily, besides RNA tumor viruses, even though it is feasible that simply those topics are particularly very important for human tumors. Tumor induction through radiation may perhaps purely be pointed out in passing, even with its nice functional value; equally the position of hormones was once basically intimated.

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J. G. Thompson, an expert on the asbestos problem, predicted that asbestos lung cancer could overtake cigarette lung cancer very soon. "Morality" and Genital Cancer American Negro women have a higher rate of genital cancer (cervical carcinoma) than white American women. 8 Racial differences appear to be responsible for these differences, but stastistics can be deceiving. Investigations in a hospital for the poor in Louisville, Kentucky showed no differences between black and white. Instead it appeared that social standing could explain the cervical carcinoma rates, in this case low social status, coincident with early sexual relations, early age at marriage, and frequent births.

The reasons were simple: relatively few molecules are bound, and they can therefore be found only when highly radioactive compounds are used. Even with the use of such "hot" material, extreme care must be used in measuring techniques in order to detect the extremely low radioactivity present. Brookes and Lawley were the first ones to demonstrate conclusively that polycyclic hydrocarbons are bound to DNA. They found further that binding and carcinogenic activity appeared to be correlated, although Goshman and Heidelberger could not completely reproduce this correlation.

Polycyclic Hydrocarbons are Bound to Protein Polycyclic hydrocarbons give a strong blue-white to yellow-white fluorescence in ultraviolet light. Using this highly sensitive detection property, E. C. Miller discovered in 1951 that 3,4-benzpyrene is bound to mouse skin protein. These experiments were the out-growth of earlier experiments which succeeded in showing the binding of carcinogenic azo dyes to liver protein (see page 36). Apparently, then, carcinogens bind to proteins of the organs in which they induce tumors.

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Cancer: Experiments and Concepts by R. Süss, V. Kinzel, J. D. Scribner (auth.)


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